Are all cyanoacrylates the same? The answer is no. It is important to know very well the characteristics of each one to know what results will be obtained after its application.

Therefore, we will explain what differentiates Glubran2 from the rest of cyanoacrylates and other solutions:

Glubran 2, manufactured by the company GEM, is a surgical glue composed of a cyanoacrylate co-monomer. That is, the union of a synthesized monomer, N-butyl-2-cyanoacrylate and methacrylosis-polano, which provides a shorter polymerization time than the rest (starting at 1 or 2 seconds and ending at 60-90 seconds) and at low temperature ( 45 ° C). Compared with other synthetic glues that usually consist only of N-butyl2-cyanoacrylate or hexyl-α-cyanoacrylate, Glubran 2 has a lower risk of unwanted phlebosclerosis, less vascular risk, since once applied it leaves a thin and flexible layer, greater control knowing perfectly the dose and time of polymerization and a much more homogeneous application thanks to its diffusion applicators. It is prepared for use, at a temperature of 4ºC, so it does not require to be frozen. It is effective in a humid environment, so it is not necessary to dry the surgical field before its application. It has a more effective access to parenchymal organs (lung, liver, etc.). Others, apply with less homogeneity. Creates a film FINE and ELASTIC, unlike others, whose film is rigid and crystalline due to a high temperature necessary for polymerization, such as hexyl-α-cyanoacrylate, which is three times more viscous, which makes it very difficult use in laparoscopy, and twice as slow in polymerization, which leads to longer waiting time for the surgeon. It is eliminated through a hydrolysis process thanks to the carboxylesterase enzyme, from 11-15 days of application to 5-6 months.

Why is Glubran 2 ideal for all types of interventions? Because each cyanoacrylate has a different composition, none offers these 5 characteristics at once except Glubran 2:

  • It acts as ADHESIVE: taking into account that its polymerization of cyanoacrylate monomers forms a very strong bond withstanding forces greater than 20 N It’s HEMOSTATIC: stops the bleeding instantly.

  • It is EMBOLIZER: it is the ONLY one with approval for internal use and ENDOVASCULAR

  • It is BACTERIOSTATIC: it stops the bacterial growth the first 10 days of the application

  • It is SEALANT: all the solutions able to go from liquid to solid state MUST AVOID the leakage, either of air or liquid. Therefore, the correct application is fundamental both in quantity and in the application method, so that it will be as homogeneous as possible.

    Among the liquid agents that exist for interventional radiology, one of the alternatives is usually the gelling agents, since they are optimal in long injections, with good control, they offer an excellent permeability nidal (in MAVS), etc. However, they are not adhesive, they are usually painful, with a more tedious technique that requires strict immobilization of the patient during fluoroscopy and, despite being more expensive, is not sclerosing, with which Glubran 2 perfectly complements those agents that do not cover all the needs of the procedure as well as can be combined with coils to have the desired embolization.

    Compared finally with foams of polidocanol + CO2, where Glubran2 is characterized by not destroying the endothelium, not fibrous and embolizing or with sponges, in which case, Glubran 2 is synthetic (without biological risks), easier to prepare and apply, is permanent and less inflammatory, it is understood why it is used in more than 3 million interventions, which support its safety and effectiveness. If you want to know more about its characteristics, uses and application techniques, consult our website or write to cardiolink@cardiolink.es.