{"id":2298,"date":"2017-06-16T09:08:58","date_gmt":"2017-06-16T09:08:58","guid":{"rendered":"http:\/\/www.cardiolinkgroup.com\/ventajas-del-uso-de-custodiol-htk-para-preservacion-de-organos\/"},"modified":"2017-07-05T12:08:37","modified_gmt":"2017-07-05T12:08:37","slug":"ventajas-del-uso-de-custodiol-htk-para-preservacion-de-organos","status":"publish","type":"post","link":"https:\/\/www.cardiolinkgroup.com\/en\/ventajas-del-uso-de-custodiol-htk-para-preservacion-de-organos\/","title":{"rendered":"Why Custodiol KTH is the best solution for organ preservation?"},"content":{"rendered":"<p id=\"tw-target-text\" class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\"><span lang=\"en\">Most already know all the solutions for preservation of organs and tissues that currently exist in the market &#8230; but do you know how they differ from each other?<\/span><\/p>\n<p class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\"><span lang=\"en\">What makes the difference (and the advantages) of using one respect to another, is the composition of the same. There are several objectives that must have this type of solutions: <\/span><\/p>\n<p class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\"><span lang=\"en\">&#8211; Firstly, maintaining a safe and reliable hypothermia will depend on the viscosity of the solution and the amount of intracellular sodium in the solution to prevent cell edema and prevent biochemical lesions. In addition, the cooling must be homogeneous and fast for a better microcirculation preservation. <\/span><\/p>\n<p class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\"><span lang=\"en\">&#8211; Secondly, to avoid reperfusion injury, such as adenosine crystalloid formation or tissue ischemia, leading to cell necrosis and an inoperative sodium-potassium pump leading to acute rejection of the graft. <\/span><\/p>\n<p class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\"><span lang=\"en\">&#8211; Finally, stabilize pH, prevent intracellular acidosis and the presence of free radicals during reperfusion and provide precursors of ATP for the rapid regeneration of the sodium-potassium pump. <\/span><\/p>\n<p class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\"><span lang=\"en\">Custodiol HTK, of\u00a0Kh\u00f6ler-Chemie (Bretschneider&#8217;s solution), fulfills all the mentioned requirements thanks to its unique composition of Histidine, Tryptophan and \u0391-Ketoglutarate, which provide:<\/span><\/p>\n<ul>\n<li class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\">Lower viscosity, which allows greater fluidity of the solution in hypothermia and better preservation.<\/li>\n<li class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\">Low Potassium content, for better systemic absorption<\/li>\n<li class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\">Low Sodium content, which protects against cellular edema<\/li>\n<li class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\">Low calcium content, allowing less infiltration of intracellular calcium during reperfusion<\/li>\n<li class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\">Unlike other solutions, it does not contain starch<\/li>\n<li class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\">High levels of Histidine, which prevents intracellular acidosis and provides greater osmotic space by doubling the capacity of buffering in the transplanted organs and maintaining stable pH<\/li>\n<li class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\">Tryptophan acts as a protective cell membrane, also preventing the presence of free radicals<\/li>\n<li class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\">The \u03b1-ketoglutarate is a key intermediate in the Krebs cycle, which provides the energy necessary for the regeneration of the Na + -K +<\/li>\n<\/ul>\n<p id=\"tw-target-text\" class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\"><span lang=\"en\">For more information on Custodiol HTK visit our division of Organ Preservation and Transplantation<\/span><\/p>\n<p>&nbsp;<\/p>\n<pre id=\"tw-target-text\" class=\"tw-data-text tw-ta tw-text-small\" dir=\"ltr\" data-placeholder=\"Traducci\u00f3n\" data-fulltext=\"\"><\/pre>","protected":false},"excerpt":{"rendered":"<p>Most already know all the solutions for preservation of organs and tissues that currently exist in the market &#8230; but do you know how they differ from each other? What makes the difference (and the advantages) of using one respect to another, is the composition of the same. There are several objectives that must have  [&#8230;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[124,90],"tags":[83,91,281,282,283,284,285],"class_list":["post-2298","post","type-post","status-publish","format-standard","hentry","category-organ_preservation","category-cardiolink-en","tag-cardiolink-en","tag-cardiolink-group-en","tag-custodiol-en","tag-htk-en","tag-kholer-chemie-en","tag-preservacion-de-organos-en","tag-solucion-de-preservacion-en"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.1.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Most already know all the solutions for preservation of organs and tissues that currently exist in the market ... but do you know how they differ from each other? 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